Kansas City Chiefs vs Los Angeles Chargers Week 1 NFL

By João Pedro Melo | Not Valid For Ontario
Published on 4 September 2025 | 17:45 - Updated on 4 September 2025 | 18:55

Chiefs vs Chargers Week 1

Recommended Bets: Chiefs vs Chargers

This Friday (5), the NFL makes its highly anticipated return to Brazil as the Kansas City Chiefs take on the Los Angeles Chargers at Neo Química Arena in São Paulo. Kickoff is scheduled for 8 PM ET, with live coverage available on TSN, RDS, and DAZN's GamePass.

Coming off a painful defeat in Super Bowl LIX, the Chiefs are aiming for a fourth consecutive trip to the big game. This season could mark the final chapter in the storied career of TE Travis Kelce. QB Patrick Mahomes and HC Andy Reid are once again leading the charge as Kansas City looks to solidify its status as the NFL’s latest dynasty.

On the other hand, the Chargers enter 2025 with hopes of building on a promising 2024 campaign under new head coach Jim Harbaugh. Harbaugh has been working closely with QB Justin Herbert to elevate the young star's game to new heights.

The Brazil matchup marks the third country outside the U.S. in which the Chargers have played. They previously appeared in international games in the United Kingdom (2008, 2018) and Mexico (2019).

Our Selected Prediction for the Match

Travis Kelce TD Anytime

Sports Interaction

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Chiefs vs Chargers Prediction: Best Odds

The best odds for the Kansas City Chiefs or for the Los Angeles Chargers to win are shown in green.

Click on the odds to access the offers from each bookmaker.

Moneyline

Chiefs

-160

Chargers

+145
+145

Spread

Chiefs -3

-110

Chargers +3

-102

Totals

Over 46.5

-109

Under 46.5

-105
All odds reflected are correct at the time of publication and are subject to change.

    Kansas City Chiefs vs Los Angeles Chargers Recent Stats

    • Kansas City Chiefs lead series 71-58-1.
    • The Chargers have lost the last 7 games against the Chiefs.
    • Travis Kelce has had 112 catches for 1,357 yards and has scored 9 touchdowns in 20 games versus the Chargers in his career.
    • QB Justin Herbert has trown for at least one TD in every single of the 9 games he played against the Chiefs.

    Chiefs vs Chargers Prediction: Market Selection

    The best sportsbook offers across different markets for props, goals, spread and player bets.

    Sportsbook

    Market

    Odds

    Bet Now

    TonyBet Logo

    Chargers under 20.5 points

    -110

    NorthStar Bets Logo

    Justin Herbert over 1.5 TD passes

    +110

    Casumo Logo

    Travis Kelce over 48.5 receiving yards

    -113

    Sports Interaction Logo

    Both teams don't score over 20 points each

    -125

    BET99 Logo

    Under 5.5 Total TDs

    -145

    Third-party payment methods may charge a fee. Deposit and withdrawal times, minimum and maximum amounts are also subject to change. Please check with your payment provider before processing.

    Our Betting Recommendation

    International games are always tough to predict. Brazilian fans are known for their passion and energy, and while the Chargers are officially the home team, the crowd will likely be dominated by Chiefs supporters.

    All eyes will be on the quarterbacks Patrick Mahomes and Justin Herbert, as well as star TE Travis Kelce and promising rookie WR Ladd McConkey. Recent matchups between these teams have been low-scoring and closely contested, so fans can expect another tight battle.

    Still, given the momentum and experience of Kansas City, the Chiefs are slight favorites to come away with the win.

    Our betting recommendation: Chiefs to win and score under 46.5 points.

    Prediction: Chiefs 20-17 Chargers

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